Synthesis of new liophilic functionalized aminomethylphosphine oxides and their acid-base and membrane-transport properties toward acidic substrates

Autor:	N. V. Kurnosova, R. A. Cherkasov, R. R. Davletshin, Airat R. Garifzyanov, A. S. Talan
Rok vydání:	2009
Předmět:	chemistry.chemical_classification Base (chemistry) chemistry Electroanalytical method Organic chemistry Substrate (chemistry) Aliphatic amine General Chemistry Membrane transport Combinatorial chemistry
Zdroj:	Russian Journal of General Chemistry. 79:1835-1849
ISSN:	1608-3350 1070-3632
DOI:	10.1134/s1070363209090114
Popis:	A large number of new lipophilic mono- and bisphosphinylamines including those possessing additional potential centers of coordination was synthesized on the basis of the Kabachnik-Fields reaction, and acid-base and membrane transport properties of the synthesized compounds toward the mono- and polybasic carboxylic acids were studied. By their basicity all the synthesized aminophosphine oxides were shown to be inferior to their aliphatic amine precursors. Introduction of the second phosphinyl group so strongly decreases the basicity that the determination of pK a by potentiometric method becomes impossible. Interrelation between the structure of aminophosphinyl carrier and substrate and the efficiency of the membrane transport of acidic substrates are discussd.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::98f8ee27d543773d4292d558c532d25b https://doi.org/10.1134/s1070363209090114 Zobrazit plný text záznamu Plný text ve formátu PDF