Multiple Myeloma: Molecular Imaging with C-Methionine PET/CT—Initial Experience
| Autor: | Donald Bunjes, Sven N. Reske, Gerhard Glatting, Anja Dankerl, Peter Liebisch, N. M. Blumstein, Christiane Wendl, Darius Kocot, Claudia Friesen |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Hyperparathyroidism Methionine medicine.diagnostic_test business.industry Standardized uptake value medicine.disease Lesion chemistry.chemical_compound medicine.anatomical_structure chemistry Positron emission tomography medicine Radiology Nuclear Medicine and imaging Radiology Bone marrow medicine.symptom Nuclear medicine business Prospective cohort study Multiple myeloma |
| Zdroj: | Radiology. 242:498-508 |
| ISSN: | 1527-1315 0033-8419 |
| Popis: | Purpose: To prospectively assess molecular imaging of multiple myeloma (MM) by using the radiolabeled amino acid carbon 11 (11C) methionine and positron emission tomography (PET)/computed tomography (CT). Materials and Methods: The study was approved by the institutional local ethics committee and the national radiation protection authorities. All patients with MM and control patients gave written informed consent. Nineteen patients with MM (11 women, eight men; age range, 42–64 years) and 10 control patients with hyperparathyroidism without hematologic diseases (six women, four men; age range, 43–75 years) underwent PET/CT 20 minutes after injection of a mean of 1.0 GBq ± 0.2 (standard deviation) 11C-methionine. Presence and extent of CT-assessed tumor manifestations and 11C-methionine bone marrow (BM) uptake were determined on the basis of maximum standardized uptake value (SUVmax). BM imaging patterns, normal BM, and maximal lesion 11C-methionine uptake in patients with MM were compared with those in c... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|