795: First trimester dysregulation of single carbon metabolism and prediction of preeclampsia
| Autor: | Ray O. Bahado-Singh, Kypros H. Nicolaides, Rita Zafra, Eliisa Loyttyniemi, Ranjit Akolekar |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Creatinine Proteinuria Carbon metabolism Eclampsia business.industry HELLP syndrome Obstetrics and Gynecology medicine.disease Gastroenterology female genital diseases and pregnancy complications Pathophysiology Preeclampsia First trimester chemistry.chemical_compound chemistry Internal medicine Medicine medicine.symptom business |
| Zdroj: | American Journal of Obstetrics and Gynecology. 206:S350 |
| ISSN: | 0002-9378 |
| DOI: | 10.1016/j.ajog.2011.10.813 |
| Popis: | eclampsia, HELLP syndrome, and normotensive controls. Patients with preeclampsia had significantly higher proteinuria (2.9 / 2.1 grams/24 hours) than either those with HELLP syndrome (0.29 / 0.93 grams/24 hours), or normotensive controls (0.10 / 0.06 grams/24 hours). The degree of podocyturia was higher in patients with preeclampsia (160 / 87 cells/mg creatinine) than in those with either normotensive pregnancies (22 / 20, p 0.02) or HELLP syndrome (21.5 / 8.6, p 0.02); no difference was observed between normotensive vs. HELLP pregnancies (p 0.5). There was a positive correlation between the degree of proteinuria and podocyturia, for the group as a whole (r 0.85, p 0.001). CONCLUSION: Flow cytometry may facilitate the use of podocyturia for both clinical and research purposes. The absence of podocyturia in patients with HELLP syndrome, with either absent or minimal proteinuria, further supports its distinct pathophysiology with respect to preeclampsia. |
| Databáze: | OpenAIRE |
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