| Popis: |
Cancer represents a major global health concern, showing high number of new cases and deaths annually worldwide. The treatment, in its turn, proves to be extremely toxic, presenting high incidence of adverse events. Therefore, designing new therapeutic approaches is an urgent need. In this context, dendrimers have been commonly applied as drug carriers, improving the pharmaceutical, pharmacokinetic, and pharmacodynamic properties of the prototype. The bioactive compound can be adsorbed on the dendrimeric structure or attached to the surface. Additionally, targeted groups can be used to promote the selective action of the drug in the human body. Hence, this chapter demonstrated the dendrimers state of art potentially directed to cancer therapy, as well as difficulties in clinical translation. |
