IRISIN: A POTENTIAL PROMISING AGENT AGAINST NON-ALCOHOLIC FATTY LIVER DISEASE IN TYPE 2 DIABETIC RATS
| Autor: | Wesam M. R. Ashour, Hany A. Elkattawy |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty business.industry Fatty liver Type 2 diabetes Malondialdehyde medicine.disease Streptozotocin 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine Endocrinology Insulin resistance chemistry Diabetes mellitus Internal medicine Myokine Medicine 030211 gastroenterology & hepatology Liver function business medicine.drug |
| Zdroj: | Al-Azhar Medical Journal. 48:207-226 |
| ISSN: | 1110-0400 |
| DOI: | 10.21608/amj.2019.56675 |
| Popis: | Background: Non-alcoholic fatty liver disease (NAFLD) is strongly related to obesity, insulin resistance and type 2 diabetes.Irisin is an exercise-induced myokine which improves glucose profile and insulin resistance. Objective: To evaluate the potential effects of irisin on liver function in type 2 diabetic rats with NAFLD and elucidate the underlying mechanisms. Material and methods: Thirty adult male albino rats were divided into 3equal groups: control rats, type 2 diabetic with NAFLD rats, and type II diabetic rats with NAFLD received irisin (0.5 μg/g body weight once daily for 8 weeks). Diabetes was induced by high fat diet for 12 weeks followed by injection of small dose of streptozotocin (35 mg/kg body weight). Eight weeks after establishment of diabetes, body mass index and abdominal circumference were estimated. Serum was analysed for glucolipid metabolic parameters, liver enzymes, C-reactive protein, tumour necrosis facror-α. Liver homogenate was assayed for malondialdehyde, superoxide dismutase, and glutathione s-transferase activities. Liver sections were stained with Hematoxlyin & eosin. Results: Irisin treatment significantly improved glucolipid metabolic parameters, liver enzymes, antioxidante enzymes accompanied by significant decrease in inflammatory mediators and malondialdehyde levels, with improvement of the histopathological findings. Conclusion: Irisin may be used as a promising agent against NAFLD in type 2 diabetic rats possibly through controlling glucose and lipid metabolism and via its beneficial anti-inflammatory and anti-oxidant effects as well. |
| Databáze: | OpenAIRE |
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