The antimicrobial properties of new synthetic porphyrins
| Autor: | Yuriy V. Ishkov, Oksana Yu. Zinchenko, Maria Yu. Rusakova, Tatyana O. Philippova, Vladimir A. Ivanitsa, B. N. Galkin, Z. I. Zhilina, S. V. Vodzinskii |
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| Rok vydání: | 2003 |
| Předmět: |
biology
Chemistry Pseudomonas aeruginosa Stereochemistry General Chemistry biology.organism_classification medicine.disease_cause Antimicrobial chemistry.chemical_compound Biochemistry Chlorin polycyclic compounds medicine Phototoxicity Candida albicans Bacterial outer membrane Escherichia coli Bacteria |
| Zdroj: | Journal of Porphyrins and Phthalocyanines. :755-760 |
| ISSN: | 1099-1409 1088-4246 |
| Popis: | The antimicrobial activity of new meso-tetrakis(N-methyl-6-quinolinyl)-substituted porphyrins and meso-tetrakis(N-methyl-6-quinolinyl)-substituted chlorins is described. The dark toxicity and photosensitising potentials of free-base (TQP and TQC) and its Sn(IV)-complexes [(TQP)Sn(IV) and (TQC)Sn(IV)] were tested on Gram-positive (Staphylococus aureus), Gram-negative (Escherichia coli and Pseudomonas aeruginosa) bacteria and two species of yeasts (Candida albicans and Rhodotorula bogoriensis). The results described in this paper show that TQP and (TQP)Sn(IV) did not inhibit the growth of S. aureus in the dark, but efficiently photosensitize the inactivation of this Gram-positive bacteria. These porphyrins have no appreciable photosensitizing activity towards Gram-negative bacteria. However, (TQP)Sn(IV) shows high dark toxicity against E. coli and P. aeruginosa. The free-base derivatives demonstrated dark activity only in the case of P. aeruginosa. We suppose that these meso-tetrakis(N-methyl-6-quinolinyl)-substituted porphyrins can bind to the Gram-negative bacteria outer membrane receptors that transported vitamin B12. The meso-substituted chlorins TQC and (TQC)Sn(IV) have shown similar efficiency in the dark- and photoinactivation of S. aureus. They revealed a middle level of dark toxicity towards Gram-negative bacteria. The Sn(IV)-complex of chlorin in comparison with free base and metalloporphyrins are more effective in photoinactivation of Gram-negative bacteria. Yeasts, such as Candida albicans and Rhodotorula bogoriensis are more sensitive to photodynamic inactivation as bacterial cells. The effects of (TQP)Sn(IV) and (TQC)Sn(IV) are more expressed than effects of free bases. |
| Databáze: | OpenAIRE |
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