High salt diet aggravates endothelial-to-mesenchymal transition in glomerular fibrosis in Dahl salt-sensitive rats
| Autor: | Hui-Lin Chen, Kuang Peng, Dian-Mei Zeng, Jun Yan, Ya-Qi Huang, Pei-Yong Jiang, Ya-Fang Du, Xiang Ling, Jie Wu |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | American Journal of Hypertension. |
| ISSN: | 1941-7225 0895-7061 |
| DOI: | 10.1093/ajh/hpad048 |
| Popis: | Background Both diabetic and hypertensive nephropathy eventually progress to glomerulosclerosis. Previous studies revealed a potential role of endothelial-to-mesenchymal transition (EndMT) in the pathophysiology of glomerulosclerosis in diabetic rats. Therefore, we hypothesized that EndMT was also involved in the development of glomerulosclerosis in salt-sensitive hypertension. We aimed to explore the effects of high-salt diet on endothelial-to-mesenchymal transition (EndMT) in glomerulosclerosis in Dahl salt-sensitive (Dahl-SS) rats. Methods Eight-week-old male rats were fed high-salt (8%NaCl; DSH group) or normal salt (0.3%NaCl; DSN group) for eight weeks, with systolic blood pressure (SBP), serum creatinine, urea, 24-hour urinary protein/sodium, renal interlobar artery blood flow, and pathological examination measured. We also examined endothelial-(CD31) and fibrosis-related protein(α-SMA) expressions in glomeruli. Results High-salt diet increased SBP (DSH vs. DSN, 205.2±8.9 vs. 135.4±7.9 mmHg, P Conclusions We demonstrated that a high-salt diet led to glomerulosclerosis involving the EndMT process, which played an essential role in glomerulosclerosis in hypertensive Dahl-SS rats. |
| Databáze: | OpenAIRE |
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