A Systematic Evaluation of the Bleomycin A2 l-Threonine Side Chain: Its Role in Preorganization of a Compact Conformation Implicated in Sequence-Selective DNA Cleavage

Autor:	Hui Cai, Dale L. Boger, JoAnne Stubbe, Timothy M. Ramsey, Silvia T. Hoehn
Rok vydání:	1998
Předmět:	Colloid and Surface Chemistry Bleomycin A2 Dna cleavage Chemistry Stereochemistry Side chain Deglycobleomycin A2 General Chemistry Biochemistry Catalysis Sequence (medicine) L-threonine
Zdroj:	Journal of the American Chemical Society. 120:9139-9148
ISSN:	1520-5126 0002-7863
Popis:	The preparation and examination of 3−7 are detailed and constitute analogues of deglycobleomycin A2 (2) containing systematic modifications in the l-threonine side chain. The studies revealed a sub...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::98e1f130f3864d6f2cd949cf04eef659 https://doi.org/10.1021/ja9816638 Zobrazit plný text záznamu