| Autor: |
Rubin, Clinton T., Sen, Buer, Xie, Zhihui, Miller, Sean, Judex, Stefan, Rubin, Janet, Yen, Sherwin S., Bas, Guniz, Uzer, Gunes, Burridge, Keith, Thompson, William R., Styner, Maya |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| DOI: |
10.17615/eqp8-v657 |
| Popis: |
A cell’s ability to recognize and adapt to the physical environment is central to its survival and function, but how mechanical cues are perceived and transduced into intracellular signals remains unclear. In mesenchymal stem cells (MSC), high magnitude substrate strain (HMS, ≥2%) effectively suppresses adipogenesis via induction of FAK/mTORC2/Akt signaling generated at focal adhesions [1]. Physiologic systems also rely on a persistent barrage of low level signals to regulate behavior [2]. Exposing MSC to extremely low magnitude mechanical signals (LMS) suppresses adipocyte formation [3] despite the virtual absence of substrate strain ( |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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