Ultrasmall MoS2 nanodots-wrapped perfluorohexane nanodroplets for dual-modal imaging and enhanced photothermal therapy
| Autor: | Xing Zhong, Weijian Chen, Haibo Zhou, anna yuan, Xueyi Zeng, Huaihong Cai, Guiting Fang, Yuping Zhang |
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| Rok vydání: | 2021 |
| Předmět: |
Materials science
010304 chemical physics Biocompatibility 02 engineering and technology Surfaces and Interfaces General Medicine Photothermal therapy 021001 nanoscience & nanotechnology 01 natural sciences chemistry.chemical_compound Colloid and Surface Chemistry chemistry 0103 physical sciences Microbubbles Medical imaging Nanodot Irradiation Physical and Theoretical Chemistry 0210 nano-technology Molybdenum disulfide Perfluorohexane Biotechnology Biomedical engineering |
| Zdroj: | Colloids and Surfaces B: Biointerfaces. 205:111880 |
| ISSN: | 0927-7765 |
| Popis: | Development of a multifunctional nanotherapeutic agent with high contrast-enhanced dual-modal imaging and photothermal therapy (PTT) efficacy is of great interest. Combination of ultrasound (US) and computed tomography (CT) imaging offers high spatial resolution images, showing great potential in medical imaging. Herein, the semiconducting perfluorohexane (PFH) nanodroplets, MoS2-PFH-PLLAs, are developed by stabilizing PFH droplets with the coating shell of poly (lactic-co-glycolic acid) (PLLA) and encapsulating the droplets with photoabsorbers of ultrasmall molybdenum disulfide (MoS2) nanodots. Upon near-infrared (NIR) irradiation, the MoS2-PFH-PLLAs can absorb the NIR light and convert it into heat, which not only promotes liquid-to-gas phase transition of PFH but also triggers photothermal heating, resulting in contrast-enhanced US/CT imaging and photothermal killing effect in vitro. Furthermore, the production of microbubbles can serve as the blasting agents to collaboratively enhance PTT efficacy after NIR irradiation. When intravenously injected into tumor-bearing mice, the MoS2-PFH-PLLAs exhibit a dual-modal US/CT imaging-guided synergistically therapeutic efficacy under NIR irradiation, resulting in tumor ablation. These nanotherapeutic agents demonstrate good biocompatibility, highly contrast-enhanced US/CT imaging, and combinational enhanced PTT efficacy. |
| Databáze: | OpenAIRE |
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