Microbial transformation of two 15α-hydroxy-ent-kaur-16-ene diterpenes by Mucor plumbeus

Autor:	Ricardo Guillermo, Braulio M. Fraga, Victoria González-Vallejo, Ignacio de Alfonso
Rok vydání:	2010
Předmět:	chemistry.chemical_classification Mucor plumbeus Ketone Stereochemistry Organic Chemistry Glycoside Epoxide Biochemistry Terpenoid Terpene chemistry.chemical_compound chemistry Drug Discovery Diterpene Ene reaction
Zdroj:	Tetrahedron. 66:227-234
ISSN:	0040-4020
DOI:	10.1016/j.tet.2009.10.105
Popis:	The microbiological transformation of candidiol (15α,18-dihydroxy-ent-kaur-16-ene) by Mucor plumbeus led to 3β,15α,18-trihydroxy-ent-kaur-16-ene, 6α,15α,18-trihydroxy-ent-kaur-16-ene, 3α,15α,18-trihydroxy-ent-kaur-16-ene, 11β,15α,18-trihydroxy-ent-kaur-16-ene and 15α,17,18-trihydroxy-11β,16β-epoxy-ent-kaurane, whilst the incubation of 15α,19-dihydroxy-ent-kaur-16-ene gave 9β,15α,19-trihydroxy-ent-kaur-16-ene, 3α,15α,19-trihydroxy-ent-kaur-16-ene, 11β,15α,19-trihydroxy-ent-kaur-16-ene, 6α,15α,19-trihydroxy-ent-kaur-16-ene, 15α,17,19-trihydroxy-11β,16β-epoxy-ent-kaurane, 19-(β-d-glucopyranosyl)-15α-hydroxy-ent-kaur-16-ene and 19-(β-d-glucopyranosyl)-15-oxo-ent-kaur-16-ene. An interesting rearrangement in dilute acid medium of 9β,15α,19-trihydroxy-ent-kaur-16-ene into 16-oxo-19-hydroxy-ent-abiet-8(9),15-diene, is also described in this work.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::98d27ebc1ae648772f02d5d7204880fd https://doi.org/10.1016/j.tet.2009.10.105 Zobrazit plný text záznamu Full Text from ScienceDirect