Biginelli condensations of fluorinated 3-oxo esters and 1,3-diketones

Autor:	C. O. Kappe, Ya. V. Burgart, O. G. Kuzueva, Oleg N. Chupakhin, Viktor I. Saloutin
Rok vydání:	2000
Předmět:	Trifluoromethyl Pyrimidine Chemistry Hexafluoroacetylacetone Organic Chemistry Biginelli reaction Condensation Thio Biochemistry Inorganic Chemistry Benzaldehyde chemistry.chemical_compound Urea Environmental Chemistry Organic chemistry Physical and Theoretical Chemistry
Zdroj:	Journal of Fluorine Chemistry. 103:17-23
ISSN:	0022-1139
Popis:	Condensation of fluorinated 3-oxo esters or 1,3-diketones with benzaldehyde and (thio)urea results in the diastereoselective formation of 4-fluoroalkyl-4-hydroxy-2-oxo(thioxo)-6-phenyl-hexahydropyrimidine-5-carboxylates from which by dehydration under acidic conditions the corresponding 6-fluoroalkyl-2-oxo(thioxo)-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylates were obtained. Under the same conditions, hexafluoroacetylacetone furnishes 4,6-dihydroxy-4,6-di(trifluoromethyl)-hexahydropyrimidin-2-one. Some further reactions of these pyrimidine derivatives leading to fused heterocycles are described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::98c8eb27e1add26af8553d0af5de6611 https://doi.org/10.1016/s0022-1139(99)00216-x Zobrazit plný text záznamu Full Text from ScienceDirect