The synthesis and biological activity of 8-fluoro-9-(4-methyl-1-piperazinyl)-6-oxo-6H-benzo[c]quinolizine-5-carboxylic acid

Autor:	Carl B. Ziegler, Thomas J. Fenton, Yang-I Lin, Daniel B. Moran
Rok vydání:	1990
Předmět:	chemistry.chemical_classification chemistry Intramolecular reaction Nucleophilic aromatic substitution Stereochemistry Carboxylic acid Organic Chemistry Nucleophilic substitution Quinolizine Electrophilic aromatic substitution Condensation reaction Antibacterial agent
Zdroj:	Journal of Heterocyclic Chemistry. 27:587-589
ISSN:	1943-5193 0022-152X
DOI:	10.1002/jhet.5570270321
Popis:	A one-pot synthesis of ethyl 8,9-difluoro-6-oxo-6H-benzo[c]quinolizine-5-carboxylate 11 has been developed. The condensation of ethyl 2-pyridylacetate and 2,4,5-trifluorobenzoyl chloride followed by intramolecular nucleophilic aromatic substitution gave the desired ring system. This intermediate was converted to the title compound and its in vitro biological activity is reported.
Databáze:	OpenAIRE
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