| Autor: |
Hendrik Niehoff, Frank Ulrich, Frank Eickmeyer, Wernholt von Tempelhoff, Hans-Joachim Schwarzmaier |
| Rok vydání: |
2006 |
| Předmět: |
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| Zdroj: |
Medical Laser Application. 21:123-130 |
| ISSN: |
1615-1615 |
| DOI: |
10.1016/j.mla.2006.03.006 |
| Popis: |
Tumours of the central nervous system represent a therapeutic challenge. Although there is a multitude of histological subgroups, the main entities are of glioma origin. The majority of these lesions have an infiltrative nature, which is, in conjunction with the vicinity of highly specialized eloquent areas, highly demanding on the surgical skills and technologies applied. These tumours will invariably recur, most often even at the very site of the apparently “complete” resection. This has created local therapies for direct intra cavitary treatment of the surface and for interstitial treatment of the immediately adjacent tissue. Sixteen patients suffering from recurrent Glioblastoma multiforme (GBM) were treated by Nd:YAG laser irradiation in the framework of a salvage therapy. The underlying concept is the cytoreduction by partial coagulation of the tumour. MRI follow-up examinations revealed a volume reduction of the laser-irradiated areas, while the untreated parts exhibited a more or less progression. The survival time after the diagnosis of the recurrence was about four times longer than the natural history of the disease would suggest. The conclusion is that cytoreduction by laser irradiation might be a promising option for patients suffering from infiltrative gliomas. Future work should optimize the therapeutic regimes and evaluate this treatment approach in controlled clinical trials. In this article we will summarize the technical and clinical results induced by interstitial laser application in cerebral gliomas. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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