Pain differences in sympathetic nervous system reactivity during simple and complex walking tasks: potential cerebral mechanisms
| Autor: | Julio A. Peraza, Pedro Valdes Hernandez, Lorraine Hoyos, Kyle D. Allen, David J. Clark, Taylor D. Yeater, Yenisel Cruz-Almeida |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Sympathetic nervous system business.industry Chronic pain medicine.disease Amygdala Anesthesiology and Pain Medicine medicine.anatomical_structure Physical medicine and rehabilitation Neurology medicine Autonomic dysregulation Neurology (clinical) Brainstem business Reactivity (psychology) Insula Anterior cingulate cortex |
| Zdroj: | The Journal of Pain. 22:601-602 |
| ISSN: | 1526-5900 |
| DOI: | 10.1016/j.jpain.2021.03.096 |
| Popis: | Autonomic dysregulation may lead to blunted sympathetic reactivity in chronic pain states and autonomic responses are controlled by the central autonomic network (CAN). Little research has examined sympathetic reactivity and associations with brain CAN structures in the presence of chronic pain; thus, the present study aims to investigate chronic pain differences in sympathetic reactivity and associations with CAN brain region volumes. Sympathetic reactivity was measured as change in skin conductance level (ΔSCL) between a resting preparation and walking phases of typical and complex walking tasks (obstacle and dual-task) in 31 participants with (n=19) and without (n=12) chronic musculoskeletal pain using a repeated measures-ANCOVA with Bonferroni corrections. Structural 3T MRI was used to determine gray matter volume associations with ΔSCL in regions of the CAN (i.e., brainstem, amygdala, insula, and anterior cingulate cortex, using partial correlations (FDR-corrected) adjusting for important covariates. ΔSCL varied across all walking tasks (main effect p=0.036), with lower ΔSCL in chronic pain participants (21.0±5.4µS) compared to controls (43.4±7.5µS). ΔSCL during typical walking was associated with multiple CAN gray matter volumes, including brainstem, bilateral insula, amygdala, right caudal anterior cingulate cortex (FDRp's |
| Databáze: | OpenAIRE |
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