| Popis: |
A study of the non-allergic, pharmacological mechanisms establishes a separate basic plane of investigation in atopic eczema (AE). Considerable clinical research is focussed at the level of environmental exacerbants while the more fundamental level — the realm of the genetically determined, constitutional predisposition to atopy — is largely ignored. Szentivanyi quoted Rackemann, who recognised this disparity in 1931: “The situation is somewhat analogous to that of a loaded gun. A good deal of knowledge is being obtained about a great variety of triggers (extrinsic and intrinsic causes) which fire the charge; but why is the gun loaded? And, what constitutes the load?” [1, 2] |
