A novel surface modification on calcium polyphosphate scaffold for articular cartilage tissue engineering
| Autor: | Sio-Mei Lien, Chun-Kuo Liu, Ta-Jen Huang |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Scaffold
Materials science Polyphosphate Cartilage technology industry and agriculture chemistry.chemical_element Bioengineering Anatomy Calcium equipment and supplies Biomaterials chemistry.chemical_compound medicine.anatomical_structure chemistry Tissue engineering Mechanics of Materials Extracellular medicine Biophysics Surface modification Secretion psychological phenomena and processes |
| Zdroj: | Materials Science and Engineering: C. 27:127-134 |
| ISSN: | 0928-4931 |
| DOI: | 10.1016/j.msec.2006.04.004 |
| Popis: | The surface of porous three-dimensional (3D) calcium polyphosphate (CPP) scaffold was modified by treatment of quenching-after-sintering in the fabrication process. Scanning electron microscopic examination and degradation tests confirmed a new type of surface modification. A rotary-shaking culture was compared to that of a stationary culture and the results showed that rotary shaking led to enhanced extracellular matrices (ECM) secretion of both proteoglycans and collagen. Rotary-shaking cultured results showed that the quenching-treated CPP scaffold produced a better cartilage tissue, with both proteoglycans and collagen secretions enhanced, than the air-cooled-after-sintering scaffolds. Moreover, β-CPP scaffolds were better for the ECM secretion of both proteoglycans and collagen than the β-CPP + γ-CPP multiphase scaffold. However, the multiphase scaffold led to higher growth rate than that of β-CPP scaffold; the quenching-after-sintering treatment reversed this. In addition, the ECM secretions of both proteoglycans and collagen in the quenching-treated β-CPP scaffold were higher than those in the air-cooled one. Thus, the novel treatment of quenching-after-sintering has shown merits to the porous 3D CPP scaffolds for articular cartilage tissue engineering. |
| Databáze: | OpenAIRE |
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