| Autor: |
Fernando José de Nóbrega, Fabio Ancona Lopez, Suzana de Souza Queiroz Tonete, Maria Eneida Aiello Sartor, Paulo Roberto Curi, Cleide Enoir Petean Trindade |
| Rok vydání: |
1983 |
| Předmět: |
|
| Zdroj: |
Nutrition Research. 3:929-945 |
| ISSN: |
0271-5317 |
| DOI: |
10.1016/s0271-5317(83)80045-1 |
| Popis: |
The objective of this study was to determine the time in which protein calorie malnutrition imposed on rats during pregnancy caused alterations in the brain composition of offspring. Results were obtained by organ weights and levels of lipids, DNA, RNA and protein in different areas of the central nervous system. Virgin rats were used and after the coitus confirmation were fed normal or deficient diet throughout or half of pregnancy and grouped accordingly. The offspring of malnourished rats were nursed by eutrophic mothers and the offspring of controls remained with their respective mothers during the 28-day lactation period. Some of the animals were killed at age 4 weeks and others kept up to adulthood. The most significant results were obtained from offspring of rats fed deficient diets throughout pregnancy. Up to the 28th day of life, offspring of rats malnourished during the first 11 days of pregnancy presented an accelerated growth reflected by the higher weights and DNA, RNA and protein content and normal lipid levels. This situation was not maintained in adulthood. Offspring of animals malnourished during the second half of pregnancy presented deficits in organ weights and DNA content up to adulthood, high RNA and protein contents in the three regions of the brain up to the 28th day of life. We conclude that depending on when it occurs, malnutrition during pregnancy alters the composition of different regions of the brain in different ways. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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