Changes in the three-dimensional microstructure of human tibial cancellous bone in early osteoarthritis

Autor:	M. Ding, A. Odgaard, I. Hvid
Rok vydání:	2003
Předmět:	business.industry Anatomy Bone healing Bone remodeling medicine.anatomical_structure Normal bone Cadaver Ageing medicine Orthopedics and Sports Medicine Surgery sense organs business Cancellous bone Three dimensional microstructure Early osteoarthritis
Zdroj:	The Journal of Bone and Joint Surgery. British volume. :906-912
ISSN:	2044-5377 0301-620X
DOI:	10.1302/0301-620x.85b6.12595
Popis:	We obtained medial and lateral subchondral cancellous bone specimens from ten human postmortem proximal tibiae with early osteoarthritis (OA) and ten normal age- and gender-matched proximal tibiae. The specimens were scanned by micro-CT and the three-dimensional microstructural properties were quantified. Medial OA cancellous bone was significantly thicker and markedly plate-like, but lower in mechanical properties than normal bone. Similar microstructural changes were also observed for the lateral specimens from OA bone, although there had been no sign of cartilage damage. The increased trabecular thickness and density, but relatively decreased connectivity suggest a mechanism of bone remodelling in early OA as a process of filling trabecular cavities. This process leads to a progressive change of trabeculae from rod-like to plate-like, the opposite to that of normal ageing. The decreased mechanical properties of subchondral cancellous bone in OA, which are due to deterioration in architecture and density, indicate poor bone quality.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::989cf62e50bbd2622716d036a8a4fb0f https://doi.org/10.1302/0301-620x.85b6.12595 Zobrazit plný text záznamu