Lack of correlation between serum corticosterone level and immune functions in undernourished mice
| Autor: | S.M. Filteau, Robert A. Menzies, Maureen P. O'Grady, T.J. Kaido, Nicholas Hall |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Nutrition and Dietetics Protein–energy malnutrition Endocrinology Diabetes and Metabolism Adrenalectomy medicine.medical_treatment Biology medicine.disease chemistry.chemical_compound Endocrinology Immune system chemistry Weight loss Corticosterone Internal medicine medicine Chronic stress medicine.symptom Glucocorticoid Hormone medicine.drug |
| Zdroj: | Nutrition Research. 13:801-813 |
| ISSN: | 0271-5317 |
| DOI: | 10.1016/s0271-5317(05)80804-8 |
| Popis: | Two models were developed in order to investigate the importance of elevated serum glucocorticoid levels in the immune dysfunction associated with protein energy malnutrition. Weight loss was induced in mice by restricting intake of a nutritionally complete diet. In one model, serum corticosterone levels of these mice were manipulated by adrenalectomy with or without a minimal maintenance level of corticosterone supplementation. This hormone supplementation was included in some animals in an effort to reduce mortality. In the second model, the amount of diet given was adjusted to produce groups of mice which were equivalently undernourished but which were either losing, maintaining or gaining weight at the time of sacrifice. Elevated serum corticosterone levels were seen only in the animals which were losing weight. Using these models, there was no consistent inverse relationship between serum corticosterone levels and blastogenic responses to mitogens, or in vivo antibody response to sheep red blood cells. The results suggest that elevated glucocorticoids may not be of major importance in the immunodepression in a chronic stress condition such as undernutrition. |
| Databáze: | OpenAIRE |
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