Global gene expression profiles in skeletal muscle of monozygotic female twins discordant for hormone replacement therapy
| Autor: | Markku Alen, Eija Pöllänen, Vuokko Kovanen, Reino Pitkänen, Urho M. Kujala, Jaakko Kaprio, Sarianna Sipilä, Jukka Puolakka, Paula H. A. Ronkainen |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Muscle tissue
0303 health sciences Aging medicine.medical_specialty medicine.drug_class Skeletal muscle Cell Biology Metabolism Biology Mitochondrion Transcriptome 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Endocrinology Transgender hormone therapy Estrogen Internal medicine medicine 030217 neurology & neurosurgery 030304 developmental biology Hormone |
| Zdroj: | Aging Cell. 9:1098-1110 |
| ISSN: | 1474-9718 |
| DOI: | 10.1111/j.1474-9726.2010.00636.x |
| Popis: | Summary Aging is accompanied by inexorable loss of muscle tissue. One of the underlying causes for this is the massive change in the hormonal milieu of the body. The role of a female sex steroid – estrogen – in these processes is frequently neglected, although the rapid decline in its production coincides with a steep deterioration in muscle performance. We recruited 54- to 62-year-old monozygotic female twin pairs discordant for postmenopausal hormone replacement therapy (HRT, n = 11 pairs; HRT use 7.3 ± 3.7 years) from the Finnish Twin Cohort to investigate the association of long-term, estrogen-based HRT with skeletal muscle transcriptome. Pathway analysis of muscle transcript profiles revealed significant HRT-induced up-regulation of a biological process related to regulation of cell structure and down-regulation of processes concerning, for example, cell–matrix interactions, energy metabolism and utilization of nutrients (false discovery rate |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|