Molecular basis of renal disease. Mechanisms and clinical significance of cell volume regulation
Autor: | August Heidland, Silvia Steuer, Giovambattista Capasso, Florian Lang, Shaul G. Massry, Siegfried Waldegger, Teut Risler |
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Rok vydání: | 1998 |
Předmět: | |
Zdroj: | Nephrology Dialysis Transplantation. 13:867-874 |
ISSN: | 1460-2385 0931-0509 |
Popis: | A wide variety of factors challenge constancy of cell volume. Alterations of cell volume activate diverse cell volume regulatory mechanisms including ion transport, osmolyte accumulation, metabolism and expression of appropriate genes. A wealth of cellular signalling pathways link cell volume to the respective regulatory mechanisms. Cell volume emerges as a pathophysiologically important parameter in several diseases including diabetes mellitus, uraemia, hepatic insufficiency and hypercatabolic states. The role of altered cell volume in disease is a challenge which requires more experimental research and clinical investigation. |
Databáze: | OpenAIRE |
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