Molecular basis of renal disease. Mechanisms and clinical significance of cell volume regulation

Autor:	August Heidland, Silvia Steuer, Giovambattista Capasso, Florian Lang, Shaul G. Massry, Siegfried Waldegger, Teut Risler
Rok vydání:	1998
Předmět:	Transplantation medicine.medical_specialty Cell division Mechanism (biology) Disease Biology Cell biology Endocrinology Nephrology Apoptosis Osmolyte Internal medicine medicine Signal transduction Gene Calcium signaling
Zdroj:	Nephrology Dialysis Transplantation. 13:867-874
ISSN:	1460-2385 0931-0509
DOI:	10.1093/ndt/13.4.867
Popis:	A wide variety of factors challenge constancy of cell volume. Alterations of cell volume activate diverse cell volume regulatory mechanisms including ion transport, osmolyte accumulation, metabolism and expression of appropriate genes. A wealth of cellular signalling pathways link cell volume to the respective regulatory mechanisms. Cell volume emerges as a pathophysiologically important parameter in several diseases including diabetes mellitus, uraemia, hepatic insufficiency and hypercatabolic states. The role of altered cell volume in disease is a challenge which requires more experimental research and clinical investigation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::988fb96a019dab7c1fa6456989c4d390 https://doi.org/10.1093/ndt/13.4.867 Zobrazit plný text záznamu