Biological effects of new corticosterone derivatives
| Autor: | R. Jequier, D. Branceni, G. Rousseau |
|---|---|
| Rok vydání: | 1965 |
| Předmět: |
Pharmacology
medicine.medical_specialty Urinary sodium Chemistry medicine.medical_treatment Organic Chemistry Clinical Biochemistry Biochemistry Steroid Excretion chemistry.chemical_compound Endocrinology Corticosterone Internal medicine medicine Prednisolone Molecular Biology Dexamethasone medicine.drug |
| Zdroj: | Steroids. 6:451-461 |
| ISSN: | 0039-128X |
| DOI: | 10.1016/0039-128x(65)90058-9 |
| Popis: | Corticosterone (I), 16α-methyl-Δ 1 -corticosterone (II) and 16α-methyl-9α-fluoro-Δ 1 -corticosterone (III) were assayed in the rat. I was found to behave as a true antiinflammatory steroid, although somewhat less active than cortisol. It exerted a kaliuretic action, but was without effect on urinary sodium excretion. The anti-inflammatory and thymolytic activities were greater in the 16α-methyl-Δ 1 derivative than in I and further enhancement was observed after 9α-fluoro substitution. II and III exerted kaliuretic and natriuretic actions. Compared to prednisolone and dexamethasone, II and III have shown, at equal anti-inflammatory dose levels, definitely lower growth inhibiting action. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|