Cortisol and Aldosterone Responses to Insulin-Induced Hypoglycemia and Sodium Depletion in Women with Non-Classic 21-Hydroxylase Deficiency
| Autor: | Sylvie Salenave, Sylvie Brailly-Tabard, Bruno Donadille, H. Bry, Céline Piedvache, Jean-François Gautier, Lise Duranteau, Julien Thomas, Yves Le Bouc, Anne Blanchard, Laurence Pietri, M. Azizi, Sophie Christin-Maitre, Marie-Laure Raffin-Sanson, Peter Kamenicky, Aurelien Lorthioir, Jacques Young, Antonin Lamaziere, Philippe Chanson, Seray Genc |
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| Rok vydání: | 2019 |
| Předmět: |
Cortisol secretion
medicine.medical_specialty Aldosterone biology business.industry food.diet Insulin tolerance test 21-Hydroxylase Furosemide Low sodium diet medicine.disease chemistry.chemical_compound Endocrinology food chemistry Internal medicine Renin–angiotensin system medicine Adrenal insufficiency biology.protein business medicine.drug |
| Zdroj: | SSRN Electronic Journal. |
| ISSN: | 1556-5068 |
| DOI: | 10.2139/ssrn.3362459 |
| Popis: | Background: Non-classic 21-hydroxylase deficiency is usually diagnosed in post-pubertal women because of androgen excess. Indication of systematic steroid replacement therapy is controversial because the risk of acute adrenal insufficiency is unknown. In order to specify this risk we evaluated the cortisol and aldosterone secretions in response to appropriate pharmacological challenges. Methods: In this prospective case-control non-inferiority study we investigated 20 women with non-classic 21-hydroxylase deficiency carrying biallelic CYP21A2 mutations and with serum 17-hydroxyprogesterone (17OHP) >10ng/mL after stimulation with Synacthen® (tetracosactrin) and 20 ageand BMI-matched healthy women with 17OHP after Synacthen® |
| Databáze: | OpenAIRE |
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