Effects of intermittent exposures of aflatoxin B1 on hepatic and testicular glutathione S-transferase in rats
| Autor: | Saura C. Sahu, Curtis N. Barton, Ming W. Chou, Rene E. Sotomayor, Dennis M. Hinton, M.W. O'Donnell |
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| Rok vydání: | 2000 |
| Předmět: |
Aflatoxin
medicine.medical_specialty biology Glutathione bacterial infections and mycoses Toxicology Enzyme assay respiratory tract diseases chemistry.chemical_compound fluids and secretions Endocrinology Glutathione S-transferase chemistry Biochemistry Internal medicine Detoxification medicine biology.protein Aflatoxin B Mycotoxin Carcinogen |
| Zdroj: | Journal of Applied Toxicology. 20:215-219 |
| ISSN: | 1099-1263 0260-437X |
| Popis: | Glutathione S-transferase (GST) plays a major role in the detoxification of the potent hepatocarcinogen aflatoxin B(1) (AFB(1)). This study evaluated the effects of intermittent exposures to AFB(1) on hepatic and testicular GST in rats. Male Fischer 344 rats were fed diets containing AFB(1) (0, 0.01, 0.04, 0.4 and 1.6 ppm) intermittently at 4-week intervals up to 20 weeks. The control animals were fed an AFB(1)-free NIH-31 diet. Rats consuming diets with 0.01 ppm AFB(1) did not show the induction of hepatic or testicular GST activity. Intermittent exposures to AFB(1) at concentrations of 0.04-1.6 ppm significantly increased the GST activities. The increase of the enzyme activity was proportional to the dose and length of AFB(1) exposure. |
| Databáze: | OpenAIRE |
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