ChemInform Abstract: Pennigritrem, a Naturally-Occurring Penitrem A Analogue with Novel Cyclisation in the Diterpenoid Moiety

Autor:	Peter G. Mantle, John N. Bilton, Jeremy R. Biddle, Richard N. Sheppard, Julia Penn
Rok vydání:	2010
Předmět:	Terpene chemistry.chemical_compound chemistry Stereochemistry Penitrem A Moiety Biological activity General Medicine Nuclear magnetic resonance spectroscopy Isoprene Terpenoid
Zdroj:	ChemInform. 23
ISSN:	0931-7597
Popis:	A prominent novel analogue of penitrem A has been resolved from the tremorgenic alkaloids of a strain of Penicillium nigricans and the structure, elucidated by NMR spectroscopy, shown to involve the terminal diterpenoid isoprene in a cyclisation which is unique amongst fungal indolediterpenoids. Consequent conformational changes in the biologically active moiety significantly reduced tremorgenicity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::987795365a7c2d944ce06ede6a54f4ea https://doi.org/10.1002/chin.199215275 Zobrazit plný text záznamu Plný text