Investigation of the cardiotoxic peptides of the venom of the cobraNaja oxiana

Autor:	L. Ya. Yukel'son, É. S. Sadykov, N. A. Barabanshchikova, A. V. Shkinev
Rok vydání:	1994
Předmět:	Chronotropic Heart preparation biology Chemistry Naja Venom Cobra Plant Science General Chemistry Phospholipase biology.organism_classification General Biochemistry Genetics and Molecular Biology Biochemistry Homogeneous computer computer.programming_language
Zdroj:	Chemistry of Natural Compounds. 30:381-385
ISSN:	1573-8388 0009-3130
DOI:	10.1007/bf00629980
Popis:	Six populations of basic polypeptides have been found in the venom of the Central Asian cobraNaja oxiana Eichwald, and four of them — V″c-1, V″c-2, V″c-5, and V″c-6 — have been obtained in the electrophoretically homogeneous state. On a perfused frog heart preparation, all the basic polypeptides proved to be cardiotoxic. However, only some of them (V′c-2, V″c-3, and V″c-4) were characterized by arrhythmic activity as well as by the negative ino- and chronotropic effects, common for all of them. An enhancement of the specific cardiotoxic effect of each of the polypeptides by pure phospholipase A-2 has been shown.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9870db872059d8008a3473a80c0cc75f https://doi.org/10.1007/bf00629980 Zobrazit plný text záznamu Full text from SpringerLink