Isatin: Role in stress and anxiety
Autor: | Alexei Medvedev, Natalia Igosheva, Michèle Crumeyrolle-Arias, Vivette Glover |
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Rok vydání: | 2005 |
Předmět: |
Endocrine and Autonomic Systems
Physiology Chemistry medicine.drug_class Monoamine oxidase Isatin Antagonist Endogeny Pharmacology Anxiolytic Behavioral Neuroscience Psychiatry and Mental health chemistry.chemical_compound Neuropsychology and Physiological Psychology Anxiogenic Atrial natriuretic peptide medicine Glucocorticoid medicine.drug |
Zdroj: | Stress. 8:175-183 |
ISSN: | 1607-8888 1025-3890 |
Popis: | (Indoledione 2,3) Isatin is an endogenous indole found both in mammalian brain and peripheral tissues. Isatin concentration in blood can exceed 1 μM and tissue concentrations vary from < 0.1 to 10 μM. Its level in the brain and periphery is increased by stress. Isatin has a wide spectrum of behavioural and metabolic effects. It is anxiogenic at lower doses and sedative at higher doses. Its most potent known in vitro actions are as an antagonist of atrial natriuretic peptide (ANP) function and NO signaling. In this review, we discuss isatin and stress in animal models, the few human studies, and also what it is known to date about the molecular mechanisms of its action. We suggest the possibility that isatin and its analogues may be interesting new pharmacological agents; Isatin antagonists may be anxiolytic, and isatin agonists may activate the HPA axis. |
Databáze: | OpenAIRE |
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