Solid-phase synthesis of benzimidazole N-oxides on SynPhase™ Lanterns

Autor:	Zemin Wu, Nicholas J. Ede, Marc N. Mathieu
Rok vydání:	2003
Předmět:	Benzimidazole chemistry.chemical_compound Solid-phase synthesis chemistry Organic Chemistry Drug Discovery Organic chemistry Biochemistry Carbonyl group
Zdroj:	Tetrahedron Letters. 44:2293-2296
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(03)00275-2
Popis:	A solid-phase synthesis of benzimidazole N -oxides was developed while attempting to synthesize 1,5-benzodiazepine-2,4-diones. The key step of the synthesis involves the reduction of an arylnitro to a hydroxyamino intermediate which subsequently condenses with an internal carbonyl group to give a benzimidazole N -oxide. A library of nine benzimidazole N -oxides was prepared on SynPhase™ Lanterns using this reduction–cyclization methodology.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::986abd6c1518847ed9b13476ece3aa7e https://doi.org/10.1016/s0040-4039(03)00275-2 Zobrazit plný text záznamu Full Text from ScienceDirect