Development of a One-Pot Tandem Reaction Combining Ruthenium-Catalyzed Alkene Metathesis and Enantioselective Enzymatic Oxidation To Produce Aryl Epoxides

Autor:	Carl A. Denard, Huimin Zhao, Mark J. Bartlett, John F. Hartwig, Yajie Wang, Lu Lu
Rok vydání:	2015
Předmět:	chemistry.chemical_classification Alkene Aryl Enantioselective synthesis Epoxide General Chemistry Metathesis Catalysis chemistry.chemical_compound chemistry Cascade reaction Biocatalysis Organic chemistry
Zdroj:	ACS Catalysis. 5:3817-3822
ISSN:	2155-5435
DOI:	10.1021/acscatal.5b00533
Popis:	We report the development of a tandem chemoenzymatic transformation that combines alkene metathesis with enzymatic epoxidation to provide aryl epoxides. The development of this one-pot reaction required substantial protein and reaction engineering to improve both selectivity and catalytic activity. Ultimately, this reaction converts a mixture of alkenes into a single epoxide product in high enantioselectivity and moderate yields and illustrates both the challenges and benefits of tandem catalysis combining organometallic and enzymatic systems.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::986a70c976e0c9217ac82261932efd68 https://doi.org/10.1021/acscatal.5b00533 Zobrazit plný text záznamu