Sensitization and photodynamic therapy of esophageal,duodenal, and colonic tumors with 5-aminolaevulinic acid (ALA) induced protoporphyrin IX (PPIX)
| Autor: | Jaroslaw Regula, Helmut Messmann, Peter Mlkvy, C. E. Millson, Stephen G. Bown, M. Pauer, M. Conio, Alexander J. MacRobert |
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| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Pathology Necrosis medicine.diagnostic_test Protoporphyrin IX business.industry Skin photosensitivity medicine.medical_treatment Photodynamic therapy Gastroenterology chemistry.chemical_compound medicine.anatomical_structure chemistry Internal medicine Biopsy medicine Duodenum Esophagus medicine.symptom business Sensitization |
| Zdroj: | SPIE Proceedings. |
| ISSN: | 0277-786X |
| DOI: | 10.1117/12.203379 |
| Popis: | Five aminolaevulinic acid (ALA) is a promising agent for PDT sensitization as it can be given orally and only causes skin photosensitivity for 1 - 2 days. In fluorescence and photodynamic studies 26 patients with benign and malignant gastrointestinal tumors (M 17, F 9; mean age 79) were given 30 - 60 mg ALA orally (single or divided doses) and biopsies taken of tumor and normal tissue at 1 - 24 hours for fluorescence microscopy. With 30 mg/kg, highest protoporphyrin IX (PPIX) levels were seen in oesophagus, duodenum and less in colon, but without tumor selectivity. Better tumor selectivity was seen in the colon after 60 mg/kg (5:1). Six patients had transient rises in transaminases and five mild nausea. Sixteen patients were later treated (after further ALA) with red light (628 nm, bare fiber or diffuser, 50 - 100 J at 50 mW at each site). All but two showed subsequent necrosis, but only 0.5 - 1.5 mm depth. PDT with ALA is simple, safe, and promising for tumors in the GI tract. Modification of treatment parameters may make it suitable for larger lesions.© (1994) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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