Arterial Hypertension and Methylenetetrahydrofolate Reductase C677T Gene Polymorphism
| Autor: | O S Pavlova, S E Ogurtsova, M. M. Liventseva, I. Y. Korobko, A G Mrochek |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
biology Homocysteine business.industry Odds ratio Gastroenterology digestive system diseases chemistry.chemical_compound chemistry Methylenetetrahydrofolate reductase Internal medicine Genotype biology.protein Medicine Gene polymorphism Restriction fragment length polymorphism Allele Cardiology and Cardiovascular Medicine business Body mass index |
| Zdroj: | Kardiologiia. 17:5-11 |
| ISSN: | 0022-9040 |
| DOI: | 10.18087/cardio.2018.10.10161 |
| Popis: | Objective: to determine the association of polymorphisms of C677T methylenetetrahydrofolate reductase (MTHFR) gene with essential arterial hypertension (EH) in the group of patients of Belarusian ethnicity. Methods. The clinical examination and molecular genetic study of the polymorphism C677T of MTHFR gene by polymerase chain reaction and restriction fragment length polymorphism analysis were performed in 423 people, including 315 patients with EH and 108 healthy individuals. Results. The distribution of C and T alleles of polymorphism C677T of the MTHFR gene in hypertensive patients was 67.8 and 32.2 %, in normotensive individuals - 71.8 and 28.2 %, respectively. In the group of hypertensive patients, the prevalence of the TT (C677T) genotype of the MTHFR gene was 10.8 %, in the healthy group - 5.5 %. The TT genotype of the C677T MTHFR gene was more common in hypertensive patients with obesity in comparison with hypertensive patients with body mass index 2 (61.8 vs 38.2 %, respectively; p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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