Pro-healing effects of bilirubin in open excision wound model in rats
| Autor: | Dinesh Kumar, Marie Dennis Leo, Anu Gopal, Surendra K. Tandan, Vinay Kant, Azad Ahmad Ahanger |
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| Rok vydání: | 2014 |
| Předmět: |
0301 basic medicine
ICAM-1 Necrosis integumentary system business.industry Bilirubin medicine.medical_treatment Granulation tissue Dermatology Pharmacology 03 medical and health sciences Hydroxyproline chemistry.chemical_compound Interleukin 10 030104 developmental biology Cytokine medicine.anatomical_structure chemistry Immunology medicine Surgery medicine.symptom business Wound healing |
| Zdroj: | International Wound Journal. 13:398-402 |
| ISSN: | 1742-4801 |
| DOI: | 10.1111/iwj.12319 |
| Popis: | Bilirubin, a by-product of heme degradation, has an important role in cellular protection. Therefore, we speculated that bilirubin could be of potential therapeutic value in wound healing. To validate the hypothesis, we used a full-thickness cutaneous wound model in rats. Bilirubin (30 mg/kg) was administered intraperitoneally every day for 9 days. The surface area of the wound was measured on days 0, 2, 4, 7 and 10 after the creation of the wound. The granulation tissue was collected on day 10 post-wounding for analysing various parameters of wound healing. Bilirubin treatment accelerated wound contraction and increased hydroxyproline and glucosamine contents. mRNA expression of pro-inflammatory factors such as intercellular cell adhesion molecule-1 (ICAM-1) and tumour necrosis factor-α (TNF-α) were down-regulated and that of anti-inflammatory cytokine interleukin-10 (IL-10) was up-regulated. The findings suggest that bilirubin could be a new agent for enhancing cutaneous wound healing. |
| Databáze: | OpenAIRE |
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