| Autor: |
Clarence Frank Bennett, Eric E. Swayze, Rich H. Griffey |
| Rok vydání: |
2007 |
| Předmět: |
|
| DOI: |
10.1016/b0-08-045044-x/00065-1 |
| Popis: |
Nucleic acids represent novel and largely unexploited targets for therapeutic agents. There are two types of nucleic acid targets, deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). The stable genetic material in cells, double stranded DNA is folded into higher order structures and is the target for several anticancer agents. RNA is a relatively unstable nucleic acid that serves a variety of functions in cells including providing structure to higher order complexes, enzymatic activity and as a template for protein synthesis. Several approved antibacterial agents target RNA structures and a burgeoning number of drugs in development target messenger RNAs and small noncoding RNAs for treatment of a variety of diseases. This review describes various nucleic acid structures which are targets of existing drugs or drugs currently in development and strategies for exploiting nucleic acids as drug targets. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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