Collagen Degradation in the Abdominal Aneurysm
| Autor: | J. Hajo van Bockel, Ratna G.V. Soekhoe, Jan H. von der Thüsen, Robert Kleemann, Ekkehard Weber, Jan H.N. Lindeman, Adri Mulder, Roeland Hanemaaijer, Hazem Abdul-Hussien |
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| Rok vydání: | 2007 |
| Předmět: |
Pathology
medicine.medical_specialty Proteases biology macromolecular substances Matrix metalloproteinase Molecular biology Pathology and Forensic Medicine Collagen type I alpha 1 Cystatin C cardiovascular system medicine biology.protein Collagenase Interstitial collagenase cardiovascular diseases Type I collagen Cysteine medicine.drug |
| Zdroj: | The American Journal of Pathology. 170:809-817 |
| ISSN: | 0002-9440 |
| Popis: | Growth and rupture of abdominal aortic aneurysms (AAAs) result from increased collagen turnover. Collagen turnover critically depends on specific collagenases that cleave the triple helical region of fibrillar collagen. As yet, the collagenases responsible for collagen degradation in AAAs have not been identified. Increased type I collagen degradation products confirmed collagen turnover in AAAs (median values: 80%). We found indications that this secondary deficiency relates to cystatin C degradation by (neutrophil-derived) proteases. |
| Databáze: | OpenAIRE |
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