Association of adiposity, measures of metabolic dysregulation, and elevated alanine aminotransferase in subjects with normal body mass index
| Autor: | Keith D. Lindor, Justo Sierra-Johnson, Virend K. Somers, Abel Romero-Corral, Sombat Treeprasertsuk, Paul Angulo, Francisco Lopez-Jimenez |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Waist National Health and Nutrition Examination Survey Apolipoprotein B biology business.industry Geography Planning and Development Management Monitoring Policy and Law medicine.disease Insulin resistance Endocrinology Normal body mass index Internal medicine Nonalcoholic fatty liver disease medicine biology.protein Alanine aminotransferase business Body mass index |
| Zdroj: | Asian Biomedicine. 8:585-596 |
| ISSN: | 1875-855X |
| DOI: | 10.5372/1905-7415.0805.331 |
| Popis: | Background: Differences in body fat (BF) distribution in patients with normal body mass index (BMI) with elevated alanine aminotransferase (ALT) remains poorly described. Objective: To determine the relationship between total BF, waist circumference (WC), insulin resistance (IR), and cardiometabolic risk profile in subjects with elevated ALT and normal BMI. Methods: We analyzed cross-sectional data from 4,914 US participants in the third National Health and Nutrition Examination Survey database, who were ≥20 years of age, had normal BMI, and had body composition assessed by bioimpedance. Results: Mean ± SD age was 41.4 ± 0.3 years, and 58% participants were women. BF was 20 ± 0.1% in men and 29.9 ± 0.1% in women. As total BF increased by tertiles, there was a tendency towards a higher prevalence of nonalcoholic fatty liver disease in men (6.1%, 6.5%, 9.5%, P = 0.13), but not in women (8.7%, 8.2%, 10.7%, P = 0.71). As WC increased by tertiles, there was a higher prevalence of elevated ALT in men (2.6%, 8.6%, 6.6%, P < 0.0001), but not in women. As ALT increased, men had significantly higher levels of nonhigh density lipoprotein cholesterol (HDL-C), increased apolipoprotein B, increased IR, and lower levels of C-reactive protein, whereas, women had higher levels of non-HDL-C and increased IR. Conclusion: In subjects with normal BMI, increased WC is associated with a higher prevalence of elevated ALT in men, but not in women. Higher levels of ALT correlated with a poor cardiometabolic risk profile. |
| Databáze: | OpenAIRE |
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