| Popis: |
In vitro culture of lymphocytes in interleukin-2 (IL-2) results in the generation of cytotoxic cells that lyse a broad spectrum of solid tumors, as well as hematopoietic cell tumors, without deliberate immunization. Peripheral blood is the source for lymphocytes used in human Lymphokine-activated killer (LAK) immunotherapy. The predominant effectors of LAK activity in peripheral blood are Natural killer (NK) cells, as defined by cells expressing CD 16 and/or Leu 19, but lacking expression of CD3. The predominant effectors of LAK activity in peripheral blood are NK cells, as defined by cells expressing CD 16 and/or Leu 19, but lacking expression of CD3. The rapid acquisition of cytotoxicity in the purified NK population implies that replication is not required for the generation of LAK activity. In conclusion, the potential for therapeutic application of IL-2 activated autologous lymphocytes has been clearly substantiated by clinical and experimental studies. |
