EVALUATION OF POLYMYXCIN B IN COMBINATION WITH CIPROFLOXACIN ANTIBIOTICS AGAINST PSEUDOMONAS AEURUGINOSA
| Autor: | P. Sutha, J. Samuel, C. Sasidhar, P. Sergin, B. Sangameswaran, T. Sudhamani, K. Nithyapriya |
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| Rok vydání: | 2023 |
| Předmět: |
Pulmonary and Respiratory Medicine
Atmospheric Science Physics and Astronomy (miscellaneous) Computer Networks and Communications Materials Science (miscellaneous) Immunology Biomedical Engineering Medicine (miscellaneous) Health Informatics Biochemistry Genetics and Molecular Biology (miscellaneous) Health Information Management Computer Science (miscellaneous) Environmental Chemistry General Materials Science Pharmacology (medical) Electrical and Electronic Engineering Pharmacology Global and Planetary Change Public Health Environmental and Occupational Health Statistical and Nonlinear Physics Cell Biology Condensed Matter Physics Agricultural and Biological Sciences (miscellaneous) Computer Science Applications Electronic Optical and Magnetic Materials Infectious Diseases Computational Theory and Mathematics Space and Planetary Science Developmental Biology Food Science |
| Zdroj: | PARIPEX INDIAN JOURNAL OF RESEARCH. :28-31 |
| Popis: | The fact that bacteria may resist various antimicrobials because they have various antimicrobial-associated genes makes them the primary cause of human infection.Therefore, this study aimed to determine the bacteria resistance to antibiotics.By using the disc diffusion method,antibiotics were tested for their susceptibility to microbes.Pseudomonas aeruginosa isolates are completely sensitive to Ciprofloxacin and Polymyxin B sulfate.This study investigated the in vitro activity of the combination of Ciprofloxacin with Polymyxin B sulphate (PMB) at different concentrations against multidrug-resistant (MDR) Pseudomonas aeruginosa.The combination effect of Ciprofloxacin and Polymyxin B sulphate antibiotics was evaluated by measuring the zone of inhibition using disc diffusion method. The minimum inhibitory concentration (MIC) of antibiotics was determined using broth microdilution.Our findings suggest that the combination of Ciprofloxacin and Polymyxin B sulphate has a synergistic effect on Pseudomonas aeruginosa. As a result, the synergistic combination reported in this study needs to be tested further in vivo before being used in clinical trials |
| Databáze: | OpenAIRE |
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