The interaction of the membrane and calcium oscillators in cardiac pacemaker cells: Mathematical modeling
| Autor: | Nikolay Zorin, Vladimir S. Markhasin, A. S. Moskvin, A. M. Ryvkin, Olga Solovyova |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Voltage-dependent calcium channel Ryanodine receptor medicine.medical_treatment Biophysics T-type calcium channel chemistry.chemical_element Cardiac action potential Calcium Biology 01 natural sciences Calcium in biology Cardiac pacemaker 010305 fluids & plasmas Endocrinology chemistry Internal medicine 0103 physical sciences medicine 010306 general physics Calcium signaling |
| Zdroj: | Biophysics. 60:946-952 |
| ISSN: | 1555-6654 0006-3509 |
| Popis: | An integrative model of the calcium dynamics in cardiac pacemaker cells is developed taking into account a synergetic effect of the interaction between an outer membrane oscillator and an intracellular calcium oscillator ("membrane and Ca(2+)-clock"). The main feature of the model is a description of the stochastic dynamics of Ca2+ release units within the electron-conformational mechanism of the functioning of ryanodine-sensitive calcium channels. It is shown that interaction of two cellular oscillators provides a stable action potential generation in the cardiac pacemaker cells even in the case of the stochastic Ca2+ dynamics. We studied in detail the effect of ryanodine channels sensitivity to an increase in the intracellular calcium concentration in sarcoplasmic reticulum and in the dyadic space on the behavior of calcium-release system. A parametric analysis of the integrative model of pacemaker cells is performed. |
| Databáze: | OpenAIRE |
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