Potent Affinity Labeling Peptide Inhibitors of Calpain

Autor:	Harlan N. Bradford, Hideaki Umeyama, Rajinder N. Puri, Robert W. Colman, Rei Matsueda
Rok vydání:	1990
Předmět:	chemistry.chemical_classification Affinity labeling Enzyme biology chemistry Biochemistry Enzyme inhibitor biology.protein Peptide Calpain General Chemistry Thiol Protease
Zdroj:	Chemistry Letters. 19:191-194
ISSN:	1348-0715 0366-7022
DOI:	10.1246/cl.1990.191
Popis:	We have employed a recently described affinity labeling approach using S-(3-nitro-2-pyridinesulfenyl) group (Npys) to devise unique inhibitors of the Ca++-dependent thiol protease, calpain. Compounds with Npys group bound on the peptides with Leu-Leu or Val-Val sequences were found to be highly potent inhibitors of calpain.
Databáze:	OpenAIRE
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