Effective total synthesis of schaftoside

Autor:	Jun Liu, Pengpeng Nie, Chengxiang Shang, Yuguo Du, Chuanfang Zhao
Rok vydání:	2021
Předmět:	Naringenin 010405 organic chemistry Chemistry Organic Chemistry Total synthesis 010402 general chemistry Ring (chemistry) 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences chemistry.chemical_compound Drug Discovery Schaftoside Dehydrogenation Lewis acids and bases
Zdroj:	Tetrahedron. 91:132216
ISSN:	0040-4020
DOI:	10.1016/j.tet.2021.132216
Popis:	A short and scalable approach toward the total synthesis of schaftoside, a naturally occurring bioactive C-glycosylflavone, has been developed from readily available (±)-naringenin. The highlights of this work are double Lewis acid promoted O→C rearrangement to form C-glycoside, oxidative dehydrogenation to construct flavone ring, and easy operational process to make the target product in multigram-scale.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::984483eff4dd74c0a1bf0bf1e0e40389 https://doi.org/10.1016/j.tet.2021.132216 Zobrazit plný text záznamu Full Text from ScienceDirect