Enzymatic radiofluorination: Fluorinase accepts methylaza-analog of SAM as substrate for FDA synthesis

Autor:	Federica Morgia, Maxim Sergeev, Pei Yuin Keng, Muhammad Rashed Javed, Mami Doi
Rok vydání:	2013
Předmět:	chemistry.chemical_classification biology Stereochemistry Chemistry Process Chemistry and Technology Substrate (chemistry) Bioengineering Fluorinase Biochemistry Catalysis Enzyme catalysis Enzyme biology.protein Substrate specificity
Zdroj:	Journal of Molecular Catalysis B: Enzymatic. 97:74-79
ISSN:	1381-1177
DOI:	10.1016/j.molcatb.2013.07.015
Popis:	Methylaza-analog of S-adenosyl- l -methionine (MeAzaAdoMet) was found to be a substrate for fluorinase. This is the first discovery of a new substrate for fluorinase that can be accessed synthetically in high purity. The activity of fluorinase for the new MeAzaAdoMet and [18F]fluoride ion was 32% in 180 min.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::98384f586f9b2044a637baed72701dc7 https://doi.org/10.1016/j.molcatb.2013.07.015 Zobrazit plný text záznamu Full Text from ScienceDirect