A sleep-like state in Hydra unravels conserved sleep mechanisms during the evolutionary development of the central nervous system
| Autor: | Sungeon Park, Etsuko Sawatari, Chunghun Lim, Aya Sato, Hiroyuki J. Kanaya, Hyunwoo Bang, Junko Kusumi, Ji Hyung Kim, Sofian Krenenou, Jongbin Lee, Taichi Q. Itoh, Yoshitaka Kobayakawa |
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| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
Multidisciplinary Ornithine aminotransferase Biology biology.organism_classification Sleep in non-human animals Cell biology Melatonin 03 medical and health sciences 0302 clinical medicine Hydra vulgaris Evolutionary developmental biology medicine Lernaean Hydra Circadian rhythm 030217 neurology & neurosurgery 030304 developmental biology medicine.drug Ultradian rhythm |
| Zdroj: | Science Advances. 6 |
| ISSN: | 2375-2548 |
| DOI: | 10.1126/sciadv.abb9415 |
| Popis: | Sleep behaviors are observed even in nematodes and arthropods, yet little is known about how sleep-regulatory mechanisms have emerged during evolution. Here, we report a sleep-like state in the cnidarian Hydra vulgaris with a primitive nervous organization. Hydra sleep was shaped by homeostasis and necessary for cell proliferation, but it lacked free-running circadian rhythms. Instead, we detected 4-hour rhythms that might be generated by ultradian oscillators underlying Hydra sleep. Microarray analysis in sleep-deprived Hydra revealed sleep-dependent expression of 212 genes, including cGMP-dependent protein kinase 1 (PRKG1) and ornithine aminotransferase. Sleep-promoting effects of melatonin, GABA, and PRKG1 were conserved in Hydra However, arousing dopamine unexpectedly induced Hydra sleep. Opposing effects of ornithine metabolism on sleep were also evident between Hydra and Drosophila, suggesting the evolutionary switch of their sleep-regulatory functions. Thus, sleep-relevant physiology and sleep-regulatory components may have already been acquired at molecular levels in a brain-less metazoan phylum and reprogrammed accordingly. |
| Databáze: | OpenAIRE |
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