| Autor: |
Mingzhe Huang, Xiaodong He, Zhengyang Li, Ting Niu, Mingming Yang, Yan Mei, Haobin Li, Jiangchao Li, Dehuan Xie, Rongxin Zhang, Lili Wei, Pinzhu Huang, Lingbi Jiang, Lijing Wang, Shihui He |
| Rok vydání: |
2021 |
| Předmět: |
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| DOI: |
10.1101/2021.01.29.428838 |
| Popis: |
Weight loss and muscle wasting can have devastating impacts on survival and quality of life of patients with cancer cachexia. Here, we have established a hybrid mouse of ApcMin/+ mice and MMP12 knockout mice (ApcMin/+; MMP12-/-) and found that knockout MMP12 can suppress the weight and muscle loss of ApcMin/+ mice. In detail, we found that interleukin 6 was highly upregulated in the serum of cancer patients and MMP12 was increased in muscle of tumor-bearing mice. Interestingly, the interleukin 6 secreted by tumor cells led to MMP12 overexpression in the macrophages, which further resulted in degradation of insulin and insulin-like growth factor 1 and interruption of glycolipid metabolism. Notably, depletion of MMP12 prevented weight loss of ApcMin/+ mice. Our study uncovers the critical role of MMP12 in controlling weight and highlights the great potential of MMP12 in the treatment of cancer cachexia. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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