Screening method for the evaluation of asymmetric catalysts for the reduction of aliphatic ketones
| Autor: | Jean-Claude Fiaud, Saoussen Zeror, Jacqueline Collin, Louisa Aribi Zouioueche, Mourad Boukachabia |
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| Rok vydání: | 2011 |
| Předmět: |
inorganic chemicals
chemistry.chemical_classification Ketone Organic Chemistry Enantioselective synthesis chemistry.chemical_element Alcohol Biochemistry Asymmetric induction Ruthenium chemistry.chemical_compound chemistry Drug Discovery Organic chemistry Enantiomer Enantiomeric excess Aliphatic compound |
| Zdroj: | Tetrahedron Letters. 52:1485-1489 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/j.tetlet.2011.01.112 |
| Popis: | ATH reductions of aliphatic ketones in water catalyzed by ruthenium coordinated by prolinamide ligands produce alcohols with moderate enantiomeric excesses in most cases. A set of seven aliphatic ketones is proposed for a rapid evaluation of the enantioselectivity of catalysts by one-pot multi-substrates reduction. The screening of a library of prolinamides shows that according to the structure of the ketones different ligands give the best asymmetric inductions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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