SHORT COMMUNICATION EFFECTS OF ?2-ADRENOCEPTOR ANTAGONISTS AND IMIDAZOLINE2-RECEPTOR LIGANDS ON NEURONAL DAMAGE IN GLOBAL ISCHAEMIA IN THE RAT
| Autor: | John A. Craven, Elizabeth L Conway |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Pharmacology
medicine.medical_specialty Adrenergic receptor Physiology Chemistry Antagonist Neuroprotection Endocrinology nervous system Gliosis Physiology (medical) Internal medicine Anesthesia medicine Hippocampus (mythology) Alpha-2 adrenergic receptor medicine.symptom Receptor Idazoxan medicine.drug |
| Zdroj: | Clinical and Experimental Pharmacology and Physiology. 24:204-207 |
| ISSN: | 1440-1681 0305-1870 |
| Popis: | SUMMARY 1. In the present study the neuroprotective effects of 3 mg/kg idazoxan, an α2-adrenoceptor antagonist and imidazolinea-receptor (I2-receptor) ligand, 3 mg/kg methoxyidazoxan, a specific α2-adrenoceptor antagonist, and 0.6 and 3 mg/kg BU224, a selective I2-receptor ligand, were evaluated following 10 min of global ischaemia in rats. 2. Neuronal cell counts in the CA1 region of the hippocampus 8 days postischaemia indicated 46–96% cell loss compared with control (P |
| Databáze: | OpenAIRE |
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