Potential Mechanisms of Metabolic SuppressionDownstream of Central A1AR Activation During Onset of Torpor

Autor: Zachary A. Barrickman, Kelly L. Drew, Lori K. Bogren, Jasmine M. Olson, Melanie M. Richter, Timothy J. Stevenson, Tulasi R. Jinka, C. Loren Buck, Brady M. Salli, Trixie N. Lee, Øivind Tøien
Rok vydání: 2012
Předmět:
Zdroj: Living in a Seasonal World ISBN: 9783642286773
DOI: 10.1007/978-3-642-28678-0_32
Popis: Hibernating animals demonstrate a nadir in metabolic demand and body temperature (T b) during torpor that is fundamental to adaptation to seasonal periods of reduced resource availability. A recent study shows how the brain regulates metabolic suppression during onset of torpor suggesting that central A1 adenosine receptor signaling is both necessary and sufficient to trigger decreases in metabolic rate and T b. This leads to an interesting question of how central signals are transduced to the periphery to elicit global suppression of metabolism and this chapter discusses relevant hypotheses.
Databáze: OpenAIRE