Relief of microecological imbalances and barrier dysfunction of the intestinal mucosa in a therapeutic strategy for life-threatening conditions
| Autor: | Roman V. Semakin, Sergej V. Chepur, L. S. Bakulina, Oleg V. Chubar, Mihail V. Vinogradov, Vasilij N. Cygan, Aleksej V. Mosin, Nikolaj N. Pluzhnikov, Sergej P. Sidorov, Mihail V. Bazhenov, Плужников Николай Николаевич (Ru) |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
business.industry Inflammatory response 030208 emergency & critical care medicine General Medicine Bioinformatics Enteral administration 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Parenteral nutrition Intestinal mucosa Histone Acetylase Intensive care Medicine Microbiome business Therapeutic strategy |
| Zdroj: | Reviews on Clinical Pharmacology and Drug Therapy. 18:197-212 |
| ISSN: | 2542-1875 1683-4100 |
| DOI: | 10.17816/rcf183197-212 |
| Popis: | Arguments are given about the expediency of early enteral treatment in life-threatening conditions to improve the functions of the intestinal barrier structures, prevent the transformation of the symbiotic microbiome phenotype and translocation of its representatives with the formation or aggravation of a systemic inflammatory response. The expediency of including proteins and beta-glucans and phosphates in the composition of nutritional mixtures was determined. For the purpose of pharmacological support, the possibility of including iron skevingers, valproates as histone acetylase inhibitors, antioxidants, statins and infusion solutions enriched with hydrogen was considered. The implementation of the paradigm of early enteral nutrition will improve the prognosis of patients in intensive care units. |
| Databáze: | OpenAIRE |
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