Do alleles at the serum amyloid A locus influence susceptibility to reactive amyloidosis in systemic onset juvenile chronic arthritis?
| Autor: | David J. Faulkes, Patricia Woo |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Amyloidosis Locus (genetics) Biology medicine.disease Juvenile chronic arthritis chemistry.chemical_compound Endocrinology High-density lipoprotein chemistry Internal medicine Immunology Internal Medicine medicine Serum amyloid A Allele Restriction fragment length polymorphism Gene |
| Zdroj: | Amyloid. 4:75-79 |
| ISSN: | 1744-2818 1350-6129 |
| DOI: | 10.3109/13506129708995274 |
| Popis: | Restriction fragment length polymorphisms of the serum amyloid A, gene have been used to distinguish three alleles:-a1, a2 and β. The relative frequencies of these alleles in patients with systemic onset juvenile chronic arthritis (S-JCA) match those in healthy control individuals. Subdivision of the S-JCA patient group, into those with and without reactive amyloidosis, reveals a highly significant co-segregation of the SAA2a2 allele with the amyloidotic condition. |
| Databáze: | OpenAIRE |
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