Abstract 11883: Mineral Metabolism Predictors of Poor Outcomes in Stable Coronary Artery Disease With and Without Impaired Renal Function

Autor: Alvaro Acena, Marta Lopez-Castillo, Ana M Pello, Juan Martinez-milla, Hans P Gaebelt, Carlos Gutierrez Landaluce, Carmen Cristobal, Nieves Tarin, Ana Huelmos, Maria L Gonzalez Casaus, oscar lorenzo, Ester Canovas, Andrea Kallmeyer, Joaquin Alonso, Jose tunon
Rok vydání: 2021
Předmět:
Zdroj: Circulation. 144
ISSN: 1524-4539
0009-7322
Popis: Background: Parathormone (PTH) is a component of the Mineral Metabolism (MM) system that has been shown recently to add prognostic value in stable coronary artery disease (SCAD) and average renal function. However, the influence of renal function on the prognostic role of PTH in pts with SCAD has not been shown yet. Our aim is to assess the influence of estimated glomerular filtration rate (eGFR) on the prognostic role of PTH and other MM markers in pts. with SCAD. Methods: We analyzed the prognostic value of MM markers (PTH, klotho, phosphate, calcidiol [25-hydroxyvitamin D3], and fibroblast growth factor-23 [FGF-23]) in 964 pts. with SCAD and eGFR Results: There were 790 pts. with HGFR and 174 with LGFR. Median follow-up was 5.1 years. In HGFR pts., predictors of ischemic events or death were plasma levels of calcidiol [HR= 0.023 (0.94-0.99) p=0.023], FGF23 [HR= 1.00 (1.00-1.003) p=0.036], non-HDL cholesterol [HR= 1.01 (1.00-1.01) p=0.026] and high sensitivity troponin [HR= 5.12 (1.67-15.59) p= 0.004], along with age [HR= 1.03 (1.01-1.05) p=0.01], treatment with statins [HR=0.36 (0.19-0.68) p=0.002], nitrates [HR= 1.13 (1.07-2.79) p=0.027], dihydropyridines [HR= 1.71 (1.05-2.77) p= 0.032], verapamil [HR= 5.71 (1.35-24.1) p= 0.018], and Proton-pump inhibitors [HR= 2.23 (1.36-3.68) p= 0.002]. In the LGFR subgroup, predictors of death or ischemic events were PTH plasma levels, [HR=1.01 (1.00-1.01) p=0.005], the eGFR [HR=0.96 (0.94-0.99) p=0.004], age [HR=1.06 (1.02-1.10) p=0.003], caucasian race [HR=0.04 (0.004-0.380) p=0.005], and treatment with insulin [HR=2.6 (1.20-5.63) p=0.015]. Conclusions: In pts. with SCAD, PTH is an independent predictor of poor outcomes only in those with eGFR
Databáze: OpenAIRE
Externí odkaz: